No. 1 Alabama will play at No. 18 Mississippi State, No. 2 Georgia will travel to No. 10 Auburn, while No. 3 Notre Dame is set to matchup with No. 7 Miami. No. 8 TCU, No. 12 Oklahoma State and No. 25 Iowa will also take on top-25 opponents on the road.
MORE: Week 11 playoff picture
Elsewhere, No. 11 Ohio State will look to bounce back from a blowout loss to Iowa when it faces No. 13 Michigan State and No. 9 Washington is set to play Stanford on Friday night.
Here’s how you can watch every AP Top 25 team in action this week (all times Eastern).